It was probably produced for Santa Maria dei Servi church in Perugia, where it remained until 1542.

It was demolished in the 1540s to make way for the moat of the Rocca Paolina and the Servites moved to the church of Santa Maria Nuova with their large collection of artworks, including Transfiguration, which was moved into that church's Graziani chapel, where it stayed until moving to its present home in 1863.

[1] The upper register shows Christ standing on a cloud in a contrapposto pose within a double mandorla and a ring of seraphim.

In the lower register are the apostles John (kneeling), Peter and James (to the right).

The composition largely reworks existing drawings made by Perugino, with the two registers and the mandorla originally used in his now lost Assumption in the Sistine Chapel.