The Tezi Altarpiece (Italian: Pala Tezi) is a painting by the Italian Renaissance painter Pietro Perugino, housed in the Galleria Nazionale dell'Umbria of Perugia, Italy.

After that monastic institute was suppressed under the Napoleonic domination of Italy, it was acquired by the Umbrian Gallery.

The panel shows the Madonna and Child on a cloud in the sky, flanked by St. Nicholas of Tolentino and Bernardino of Siena.

Below, over a wood landscape, are the traditional depictions of St. Jerome with the lion, and St. Sebastian struck by arrows.

Also, the use of colors is not typical of Perugino, and the work was perhaps executed mostly by his workshop, with the master adding just some touches.