The distant origins of the village are more obscure, however it is believed to have been founded in the period following the failed 1611 uprising against the Ottomans in Epirus led by Dionysius the Philosopher of Ioannina.

Anogeio is located in the high ground above the strategic pass of Pente Pigadia, on the road linking Ioannina with Preveza and southern Epirus.

The Turkish army, well aware of the strategic implications of the pass, led a determined assault against the Greek positions at Anogeio on 11 October 1912.

Anogeio is the homeland of the Rentzaioi clan, two members of which achieved notoriety through being chief suspects for one of the biggest bank robberies in the history of the region.

15 million drachmas, a substantial sum for the time, were stolen from the vehicle and 8 members of the security crew were found murdered at the scene.

Petty local officialdom and state authority were held in general disregard, a phenomenon accentuated by the remoteness of the mountain settlements.