In enzymology, a leucocyanidin oxygenase (EC 1.14.11.19) is an enzyme that catalyzes the chemical reaction The 3 substrates of this enzyme are leucocyanidin, 2-oxoglutarate, and O2, whereas its 5 products are cis-dihydroquercetin, trans-dihydroquercetin, succinate, CO2, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen.
This enzyme is also called leucoanthocyanidin dioxygenase (LDOX) or anthocyanidin synthase (ANS).
[1] The gene encoding the enzyme (PpLDOX) has been identified in peach[2] and expression has been studied in Vitis vinifera.
[3] As of late 2007, only one structure, in Arabidopsis thaliana, has been solved for this class of enzymes, with the PDB accession code 2BRT.