Antigua and Barbuda competed at the 2015 Pan American Games in Toronto, Ontario, Canada from July 10 to 26, 2015.

Track and field athlete Daniel Bailey was the flagbearer for the team during the opening ceremony.

The team was cut in half after the Pan American Sports Organization had to pare down the number of athletes after double the original quota qualified.

[3] Antigua and Barbuda has qualified one male cyclist, and later received a wildcard quota in the women's events.

[3] Antigua and Barbuda received two universality spots (one male and one female).