Part of the North Shewa Zone, Antsokiyana Gemza is bordered on the south by Efratana Gidim, on the southwest by Menz Gera Midir, on the west by Gishe, and on the north and east by the Oromia Zone.

The administrative center is Mekoy; other towns in Antsokiyana Gemza include Majete.

Local landmarks in this district include the Tomb of Saint Gelawdewos, where the head of the holy emperor of that name was buried in 1562.

The majority of the inhabitants were Orthodox Tewahedo, with 74.35% reporting that as their religion, while 23.83% of the population said they were Muslim and 1.81% were P'ent'ay.

The majority of the inhabitants were Orthodox Tewahedo, with 75.98% reporting that as their religion, while 23.15% were Muslim, and 0.82% Protestant.