The Oswegatchie River flows through the northern part of the town and loops back at Oxbow.

The southeastern portion of Antwerp contains part of the Fort Drum Military Reservation.

Albert Woolson, an American Civil War veteran and the last surviving member of the Grand Army of the Republic, was born in Antwerp.

[7] Artist Cassius Marcellus Coolidge, noted mainly for his paintings depicting dogs playing cards, was born and raised in Antwerp, started its first bank, and is buried there.

He is also credited with inventing carnival cut-outs, the painted backdrops with faces missing, enabling individuals to pose for novelty photos.

Hoard, businessman and member of the United States House of Representatives, lived in Antwerp and served as postmaster before relocating to Watertown in the 1840s.

[10] John Harris, Wisconsin state senator and businessman, was born in Antwerp.