It flows southeast from the Nulato Hills to its mouth on the larger river 1.5 miles (2.4 km) north of Anvik.

[4] The river has excellent fishing for four species of salmon as well as northern pike, sheefish, Arctic char, rainbow trout, and grayling.

[5] Rated Class 1 (easy) on the International Scale of River Difficulty, about 121 miles (195 km) of the Anvik is suitable for floating by open canoes, folding boats and kayaks, and inflatable canoes, kayaks, and rafts.

Floatplanes, riverboats, and wheeled airplanes that can land on gravel bars can transport boaters as far as McDonald Creek, near the headwaters.

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