Appignano del Tronto is a comune (municipality) in the Province of Ascoli Piceno in the Italian region Marche, located about 80 kilometres (50 mi) south of Ancona and about 9 kilometres (6 mi) northeast of Ascoli Piceno.

Appignano del Tronto borders the following municipalities: Ascoli Piceno, Castel di Lama, Castignano, Offida.

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