The Aquarius Mountains are on the perimeter of the transition zone, and border the south-flowing Big Sandy River and Valley on its west; adjacent further west is the massif of the Hualapai Mountains, a block faulted Basin and Range landform bordered westwards by the north–south Sacramento Valley.

The merged area of the two ranges in the north contains Trout and Knight Creeks, both westward-flowing towards the Big Sandy River & Valley ( both due-south trending along a fault).

[2] The second highest peak in the range occurs in the extreme southwest, Grey Mountain, 5,261 feet (1,604 m) in the Aquarius Cliffs, part of the Aquarius Fault, a southern extension from the Grand Wash Cliffs and Fault.

U.S. Route 93 travels north–south through the Big Sandy River Valley on the range's west.

At Wikieup, Arizona at the range's southwest, and near Neale and Goodwin Mesas, Route 93 turns southeast to Wickenburg, about 65 mi (105 km) distant.