U.S. Route 70 (US 70) runs east–west through across the heart of Arkansas for 287.2 miles (462.2 km).

US 70 enters the state from Oklahoma west of De Queen, and exits to Tennessee at Memphis, running concurrently with Interstate 55 (I-55), US 61, US 64, US 78, and US 79.

Between Oklahoma and Hot Springs National Park, US 70 is largely rural and two-lane.

The route bypasses much of the city to the south and then serves as the arterial road between Hot Springs National Park and Little Rock.

Between North Little Rock and its merge into I-55 at West Memphis, the route is principally two-lane and has been supplanted by I-40, which always runs within a few miles of the highway.