181) is a designation for five segments of state highways in Mississippi County.

[2] A second route, consisting of four segments connected by other state highways, of a total length of 31.19 miles (50.20 km) begins at Highway 14 in Marie and runs north to Missouri SSR-NN.

[2] Highway 181 begins at US 61 in Bassett and runs west to Interstate 55.

The highway passes the Widner-Magers Farm Historic District and continues north then east at Woodland Corner.

The route then turns north to terminate at MO-SSR-NN at the Missouri state line.