Along the route are many National Register of Historic Places properties, Civil War battlefields, parks, and other archeological and culturally significant points.

The parkway was designated as an Arkansas Scenic Byway in 1997 as a motor route which allowed the traveler to experience the Southern heritage of the area.

Winding through the forest as a narrow two-lane road, the parkway passes Storm Creek Lake and enters Lee County (now following CR 217).

Now facing north, the parkway passes the historic Campbell House and the Stuart Springs before joining with Highway 284 and crossing over Interstate 40/US 63 (I-40/US 63).

Continuing north, Crowley's Ridge Parkway passes East Arkansas Community College before forming the western boundary of Village Creek State Park and entering Cross County.

Crowley's Ridge Parkway continues through unique countryside and American Civil War era battlefields in the Missouri Bootheel.