The route skirts Lake Maumelle, the Ouachita National Recreation Trail, the Arkansas River, and Pinnacle Mountain State Park crossing both the Big and Little Maumelle Rivers (as well as the Pegasus Pipeline) while serving many unincorporated communities including Wye, Little Italy, Monnie Springs, Roland, Natural Steps, and Pinnacle before terminating at Highway 10 (Cantrell Road) in Little Rock near the base of Shinall Mountain.

Immediately prior to this terminus, Highway 300 intersects Chenal Parkway, a thoroughfare connecting the route to Little Rock's Financial Centre District.

In the 1920s, a one-lane truss bridge was built on Highway 300 to cross the Big Maumelle River.

It is part of the Ouachita National Recreation Trail and is visible from the current bridge.

The spur then continued north along Ledwedge Road toward the community of Ledwidge near the Little Rock and Western Railway and the Arkansas River.