The route begins at an intersection with US 64 west of Wynne in the Arkansas Delta.

Although even-numbered routes are signed east–west, Highway 350 runs north-south except for the last 2.5 miles (4.0 km).

The route is two-lane, undivided, passing through sparsely populated agricultural territory.

The highest average daily traffic observed in 2014 was 940 vehicles per day (VPD) on the southern section.

The routes form a concurrency south to McElroy, where Highway 284 turns west to Penrose, with Highway 350 continuing due south as a section line road.