[3] Highway 50 begins at CR 415 north of Forrest City and runs south across Interstate 40 (I-40), although there is no interchange.

Continuing east, a short concurrency begins with Highway 149, ending near Greasy Corner.

Highway 50 begins northwest of Edmondson at US 70, which acts as a frontage road for I-40/US 63/US 79.

In Crawfordsville, Highway 50 briefly overlaps US 64B before crossing US 64 just north of town.

The highway continues north before later turning east to a junction with I-55/US 61/US 63 in Clarkedale.