The route of about 41.28 miles (66.43 km) runs from Highway 38 in Hughes north across Interstate 40 (I-40) and I-555 to AR 140/AR 75/AR 14 in Marked Tree.

After the concurrency ends, Highway 149 turns due north and runs through fields.

Shortly after this junction the route enters Crittenden County and runs north to Earle.

The concurrent routes passes near the Crittenden County Museum, listed on the National Register of Historic Places (NRHP) before Highway 149 turns north onto Barton Street, ending the concurrency.

[4] The road curves through Arkansas delta countryside to a concurrency with Highway 42, beginning at Three Forks.