Arnold Eskin

In his early scientific career, Eskin studied circadian rhythms in the house sparrow, while working in chronobiologist Michael Menaker's lab at the University of Texas at Austin.

Eskin's most cited paper while in Menaker's lab concerns his research of non-ocular entraining cues in house sparrows.

His lab focuses on the role of the circadian clock and the regulation of glutamate uptake in synaptic plasticity, using aplysia and rats as model organisms primarily.

[5] Eskin's group believes that the mechanism for glutamate uptake is phylogenetically conserved for multiple types of synaptic plasticity.

[8] The Eskinogram has notably been used to model how the suprachiasmatic nucleus (SCN) acts as a master oscillator for the human biological clock.

A group of photoreceptors called the intrinsically photosensitive retinal ganglion cells (ipRGCs) act as the input for the clock mechanism.

The SCN then uses a transcription-translation feedback loop, consisting of a set of clock genes that regulate their own expression, to act as a complete oscillator and signal locomotor outputs accordingly.