In the past, the Arroyo Valle had a significant steelhead migration; however, degradation of the stream in the latter half of the 20th century has decimated this anadromous fish population.

[7] San Antonio Creek's origin is on the western slope of 3,804 feet (1,159 m) Mount Stakes, west of the Santa Clara-Stanislaus County border, about 32 miles (51 km) southeast of Livermore.

[8] In the middle reaches of Arroyo Valle south of Livermore, there has been considerable historic grazing use.

[9] Subsequent to this reach, the Arroyo del Valle flows down the moderately sloping hills to enter gravel pits, where extraction (but not processing) has historically been conducted by Lone Star Industries.

Historically, Arroyo Valle was connected to Tulare Lake, a lagoon in the Livermore-Amador Valley, and thus to the Alameda Creek watershed.