In humans, arylsulfatase A is encoded by the ARSA gene.

[5][6] A deficiency in Arylsulfatase A is associated with metachromatic leukodystrophy, an autosomal recessive disease.

[7] Multiple sulfatase deficiency (MSD) is also associated with the ARSA gene.

[8] Arylsulfatase A is inhibited by phosphate, which forms a covalent bond with the active site 3-oxoalanine.

This hydrolase article is a stub.