Galactosylceramidase (or galactocerebrosidase), EC 3.2.1.46, is an enzyme that removes galactose from ceramide derivatives (galactosylceramides) by catalysing the hydrolysis of galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride.
[1] It is a lysosomal protein, encoded in humans by the GALC gene.
[1][2] Mutations in this gene have been associated with Krabbe disease, also known as galactosylceramide lipidosis.
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