In addition to videos explaining scientific news and research, the channel produces songs, several of which have achieved viral fame and also created controversy.

[6] Moffit and Brown are an openly gay couple who met while studying biology at the University of Guelph.

[7] They made their sexualities and relationship public online in 2014, two years after starting their channel, in response to derogatory comments and in order to be visible role models for young gay people interested in science.

[13] In March 2015, Moffit and Brown released their first book, AsapSCIENCE: Answers to the World's Weirdest Questions, Most Persistent Rumors, and Unexplained Phenomena.

[14] AsapScience has collaborated with Vsauce3 on 4 videos, The Scientific Secret of Strength and Muscle Growth, What if Superman Punched You?, Can We Genetically Improve Intelligence?

On December 7, 2023, Mary Simon, the Governor General of Canada, invested both Brown and Moffit with the Meritorious Service Medal (Civil Division) for using "explanations, solid facts and humour" to "educate the Internet generation about science topics".