[3] The channels feature videos on scientific, psychological, mathematical, and philosophical topics, as well as gaming, technology, popular culture, and other general interest subjects.

[15] A new branding scheme designed by Natasha Jen was adopted in December 2014 to bring a "grown-up" feel to the channels.

It utilizes the DIN Next Rounded font and fluid designs to convey the idea of sauce that the name "Vsauce" implies.

[18] Stevens collaborated with educator and television personality Adam Savage in 2017 for a show titled Brain Candy Live.

Since 2019, Vsauce2 has largely produced videos regarding probability, paradoxes, and dilemmas, most of which are mathematical or economic in nature and visualized through real-world situations.

In November 2018, Lieber and channel producer Matt Tabor launched The Create Unknown podcast, which interviews digital creators.

[28] The podcast has featured interviews with Casey Neistat, Derek Muller from Veritasium, Destin Sandlin from Smarter Every Day, Dolan Dark, iDubbbz, and Grandayy.

He has also presented videos with celebrity guest appearances from Bill Nye, Jack Black, The Muppets, Paul Rudd, and Neil deGrasse Tyson.

[31] On December 19, Jake announced that he had begun treatment and a tumor on his lower leg had been successfully removed by surgery.

[citation needed] D!NG, formerly DONG (Do Online Now, Guys), is a spin-off channel by Vsauce that features unusual pages, apps, and games from around the Internet.

[34] Some people or channels Michael Stevens of Vsauce1 has collaborated with include Bill Nye, BrainCraft, Derek Muller, Good Mythical Morning, The Filthy Frank Show, and others.