In 1688, Shōgun Tokugawa Tsunayoshi elevated his mother’s half-brother, Honjō Munesuke, to the rank of daimyō and assigned him a 10,000 koku territory on the former Ashikaga lands.

He was later awarded an increase to 20,000 koku before being transferred to Kasama Domain in Hitachi Province in 1692.

In 1705, despite his somewhat advanced age, the hatamoto Toda Tadatoki received an additional 3000 koku in addition to his existing 8000 koku by Shōgun Tokugawa Ienobu as a reward for his long service, and Ashikaga domain was revived.

The final daimyō, Toda Tadayuki served the Tokugawa shogunate as Rikugun bugyō, but later switched allegiance to the pro-imperial cause in the Boshin war of the Meiji restoration.

After the abolition of the han system in July 1871, Ashikaga Domain became part of Tochigi Prefecture.