Sekiyado Domain (関宿藩, Sekiyado-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Shimōsa Province (the northern portion of Chiba Prefecture and southern portion of Ibaraki Prefecture in modern-day, Japan).
Prime Minister Baron Suzuki Kantarō was born as the son of a samurai of Sekiyado Domain.
Following the Battle of Odawara in 1590, the Kantō region by was assigned by Toyotomi Hideyoshi to Tokugawa Ieyasu, who appointed his half-brother Matsudaira (Hisamatsu) Yasumoto as daimyō of the newly formed Sekiyado Domain, with revenues of 20,000 koku.
After the Battle of Ueno, the final daimyō of Sekiyado, Kuze Hironari, submitted to the new Meiji government.
He was appointed domain governor under the new administration, until the abolition of the han system in July 1871 and subsequently became a viscount under the kazoku peerage.