The Karasuyama Ōkubo clan maintained a secondary jin'ya in what is now Atsugi, Kanagawa to administer its extensive holdings in Sagami Province.
During the late Sengoku period, partly for failing to participate in the 1590 Battle of Odawara, Toyotomi Hideyoshi divided their holdings, creating Nasu Domain (20,000 koku) for the Nasu clan, and awarding their ancestral castle, Karasuyama Castle and 20,000 koku to Narita Ujinaga.
Ujinaga’s son Narita Ujitada fought on the side of Tokugawa Ieyasu against the Uesugi clan and in the Battle of Sekigahara and was awarded an increase to 37,000 koku.
However, the Nasu were dispossessed by Shōgun Tokugawa Tsunayoshi following a succession dispute, and were replaced by Nagai Naohiro (1687–1701), who later was transferred to Ako Domain after its confiscation from Asano Naganori following the Forty-seven rōnin incident.
After the abolition of the han system in July 1871, Karasuyama Domain became part of Tochigi Prefecture.