Contestants who have previously participated in another Top Model franchise can still apply for the competition as long as they were not the winner, and are not currently under contractual obligations with an agency or endorsing any product or brand.

In contrast the American version, the contestants receive instruction from a mentor who helps coach them in various aspects of the modelling industry and acts as a general assistant during photo shoots and challenges.

For the sixth cycle, Cindy Bishop and Yu Tsai returned to the panel as the host and creative consultant of the show, respectively.

Subaru executive Glenn Tan, who was a guest panelist in the fourth episode of cycle 4, sparked backlash on social media after reprimanding South Korean contestant Sang In Kim.

"[5] In May 2016, twelfth-placing contestant Mai Ngo Quynh, from Vietnam, was fined VND22,500,000 (US$1,000) by the Ministry of Culture, Sports and Tourism (MCST), after it was ruled that she had entered Asia's Next Top Model illegally.

Vietnam's official rules specify that all people who participate in beauty competitions abroad must obtain secure permission from the MCST and have won at least one national title.

The first, fifth and sixth cycle of the series were free to watch on the show's official YouTube channel, but the videos are currently set to private viewing.