Asiedu Nketiah was born in Seikwa B/A in the Wenchi Municipal District which was then part of the Bono Ahafo Region but now in the Bono Region of Ghana on 24 December 1956, to Nana Kwaku Asiedu, a farmer from the Oyoko Royal family and Madam Hagar Akosua Afrah of the Akwamu Royal family.

He began his career as a professional teacher at Seketia Presby Primary in the Jaman North District[6] of the Bono region.

He obtained a Master of Science Degree in Defense and International Politics from the Ghana Armed Forces Command College[9] in 2019.

[19][20] He was re-elected into the 2nd parliament of the 4th Republic of Ghana and represented during the 1996 Ghanaian general election on the ticket of the National Democratic Congress.

[21] In the year 2000, Asiedu Nketia won the Ghanaian general elections as the member of parliament for the Wenchi West constituency of the Brong Ahafo Region of Ghana.

[24][25]In 2017, Mr Asiedu Nketiah was elected[26] Vice President of Socialist International in absentia at Cartagena to succeed the former Prime Minister of Portugal and current UN Secretary-General, António Guterres.

He was elected to serve under the current President of the Organization, George Papandreou, who doubles as the Prime Minister of Greece.