[1] NPRA and NPRB are linked to guanylyl cyclases, while NPRC is G-protein-linked and is a "clearance receptor" that acts to internalise and destroy the ligand.
cGMP will then stimulate cGMP-dependent protein kinase (PKG), which will then induce smooth muscle relaxation.
The nitric oxide will then diffuse into the vascular smooth muscle and will activate the soluble guanylyl cyclase.
The nitroglycerine will be metabolized to nitric oxide, which will stimulate soluble guanylyl cyclase.
Weaker contractions will lead to more blood flow in the coronary arteries, which will help the ischemic cardiac myocytes.