[1][2] Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled.
Numerous crystal structures have been reported for the neurotensin receptor 1 (NTS1).
[3] The third receptor has a single transmembrane domain and is encoded by the SORT1 gene.
Unusually for GPCRs, NTS1 can be expressed in an active form in the bacteria E.
[8] It can be purified and analysed in vitro and has been analysed by a number of biophysical techniques such as surface plasmon resonance,[9] FRET[10] and cryo-electron microscopy.