[5][6][7] Common side effects include headache, trouble sleeping, sleepiness, and unsteadiness.

[5] Serious side effects may include high blood lactate levels, psychiatric symptoms, and enlargement of the liver.

[5] Common side effects of efavirenz/emtricitabine/tenofovir are tiredness, dizziness, gastrointestinal distress, and skin discoloration.

Additionally, St. John's wort is known to reduce the effectiveness of efavirenz/emtricitabine/tenofovir, resulting in increased viral load and possible resistance to efavirenz/emtricitabine/tenofovir.

These three drugs work in combination to target the HIV reverse transcriptase protein in three ways, which reduces the virus's capacity to mutate.

[15] An equivalent two pill regimen is available in developing countries at a price of about US$1.00 per day, as Gilead Sciences has licensed the patents covering emtricitabine/tenofovir to the Medicines Patent Pool[16] and Merck and Co makes efavirenz available in developing countries at a reduced price.