Aubignan (French pronunciation: [obiɲɑ̃]; Occitan: Aubinhan) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France.

Close to Beaumes-de-Venise and the famous Côtes du Rhône vineyards, Aubignan is, itself, locally famous for the production of wine, and of young vines and vine grafts.

The village is located to the North of Carpentras, and is part of the Comtat Venaissin.

The commune is twinned with Cheseaux-sur-Lausanne, Switzerland, and Barrow-and-Littleton, United Kingdom.

The three most important railway stations are Avignon, Orange and Carpentras.