[2] Signs and symptoms that are consistent in an individual affected with autoimmune polyendocrine syndrome type 2 are the following:[1][4][6] In terms of genetics one finds that autoimmune polyendocrine syndrome type 2 has an autosomal dominant pattern of inheritance, with an incomplete penetrance.

[7][8] Furthermore, the human leukocyte antigen involved in this condition are HLA-DQ2(DR3 (DQB*0201)) and HLA-DQ8(DR4 (DQB1*0302)),[9] genetically speaking, which indicates this is a multifactorial disorder, as well.

[1][10] Should any affected organs show chronic inflammatory infiltrate (lymphocytes), this would be an indication.

Moreover, autoantibodies reacting to specific antigens is common, in the immune system of an affected individual.

[11] Other methods/exam to ascertain if an individual has autoimmune polyendocrine syndrome type 2 are:[3] Management of autoimmune polyendocrine syndrome type 2 consists of the following:[4] The condition was recognized by Martin Benno Schmidt (1863 – 1949), a German pathologist, first described in 1926.