The original icon enshrined above the main altar came from Germany before priests of the Redemptorist Order brought it to what was then the United States territory of the Philippine Islands in 1906.

The Bantayog ng mga Desaparecido monument within the church compound was inscribed in 2019 in the CIPDH-UNESCO's Memorias Situadas, which maps international sites of memory linked to serious human rights violations.

Denis Grogan, the builder, was dedicated to Saint Thérèse of Lisieux and made her patroness of the new church and parish house.

However, the Ynchaustí family, long-time supporters and friends, donated a high altar on the condition that it enshrine the icon of Our Mother of Perpetual Help.

[2] The icon was initially thought lost until a De La Salle brother found it among other valuable objects that the Japanese had seized and abandoned at the Old Bilibid prison.

[2] Contrary to popular belief, the Perpetual Help Novena did not originate in Baclaran, but at the Redemptorist Church dedicated to Saint Clement Hofbauer in La Paz, Iloilo City, first held on May 6, 1946.

[1] In February 1973, Archbishop of Kraków, Cardinal Karol Wojtyła offered a Catholic Mass at the shrine during a brief, unofficial stopover in Manila.

Thirty-five technicians who were operating the COMELEC's electronic quick count staged a walkout from their headquarters at the Philippine International Convention Center to protest alleged electoral fraud by supporters of dictator President Ferdinand Marcos.

[9] Marcos's wife, Imelda, was a benefactress of the shrine and devotee, having often brought her children there to perform the Visita Iglesia during Holy Week.

[11] On June 27, 2023, the feast day of Our Mother of Perpetual Help, the shrine was declared an Important Cultural Property by the National Museum of the Philippines.

[citation needed] When the early Redemptorists settled at Baclaran, they insisted that the church besides their convent will not become a parish but a mission station in order to free them from sacramental work, except for the Eucharist and Penance.

Redemptorists chose this arrangement to concentrate on fostering devotion to Our Mother of Perpetual Help, the administering of Sacrament of Penance, and mission work, particularly with the poor in Manila and wider Tagalog-speaking region.