The east-west aligned Palatine Ludwig Railway (Pfälzische Ludwigsbahn) was built from Rheinschanze (since 1853: Ludwigshafen) to Bexbach between 1847 and 1849.

The reason for this was the hope for better coal traffic to the southern German countries of Baden, Württemberg and the rest of the Bavaria—which was geographically separated from the Circle of the Rhine (Rheinpfalz).

However, resistance came from the town of Germersheim, which urged them to build a railway line first through its territory and from there to Bruchsal.

In addition, in 1860, several representatives of South Palatinate communities gathered together and petitioned against a route via Winden and Kandel instead argued for a line from Landau via Offenbach, Herxheim, Leimersheim and Leopoldshafen to Karlsruhe.

From this time onwards, until the outbreak of the First World War, all of the express trains coming from Ludwigshafen used this route; these previously had to detour via the Palatine Maximilian Railway.

[16] After the war, Alsace-Lorraine, which had belonged to the German Empire since 1871, was given back to France and long-distance traffic on the Wörth–Strasbourg railway was permanently transferred to lines through neighbouring Baden.

After the Second World War, the section between Winden and Wörth was reconstructed as one track during the French occupation to provide reparations.

[23] On 26 September 1997, the S5 ran past the former terminus of the tramline in central Knielingen over a connecting line including a system change and onto the Winden–Karlsruhe railway.

Starting from Wörth station, a new line was opened for the Stadtbahn through the residential area of Dorschberg, which had been built in the post-war period.

[24] In 2002, passenger services were reactivated between Wörth and Lauterbourg; for marketing reasons, this section has been designated as the Bienwaldbahn (Bienwald Railway).

[26] At the timetable change of 2010/2011, the southern section of the Schifferstadt–Wörth railway (Germersheim – Bellheim – Rheinzabern – Wörth) was included in the network of the Karlsruhe Stadtbahn.

Since then the newly created lines S51 and S52 have been running directly between the Karlsruhe inner city, Wörth and Germersheim.

[30] In local rail transport, there are direct connections with one Regional-Express and three Regionalbahn services to Karlsruhe, Winden (Pfalz), Landau (Pfalz), Neustadt (Weinstraße), Kaiserslautern, Germersheim, Speyer, Schifferstadt, Ludwigshafen am Rhein and Lauterbourg in Alsace.

In long-distance transport, the station was served from Monday to Friday by a pair of Intercity services on the Karlsruhe–Frankfurt route in the 2013/2014 timetable.

Just a few years after its inauguration, it was home to numerous factory sidings, which served local industry and trade.

In addition, due to its proximity to the French border, it developed into an important customs and transhipment centre.

[31] It is now mainly used for transporting cranes from the surrounding recreational lakes in former quarries (baggerseen) as well as for loading new trucks.

The Albtal-Verkehrs-Gesellschaft (AVG) has long been called for connections to the towns of Landau and Bad Bergzabern on the Karlsruhe Stadtbahn network.

The state government of Rhineland-Palatinate intends to support this project and to take the necessary measures included in the Federal Transport Plan (Bundesverkehrswegeplan) of 2015.