'Tuscan National Bank') was a credit institution and bank of issue of the Grand Duchy of Tuscany, founded by merger in 1860.

[2] After the national unification of 1861, the Banca Nazionale Toscana was one of six remaining Italian banks of issue, together with the Banca Toscana di Credito, Banca Romana, Banco di Napoli, Banco di Sicilia, and National Bank of the Sardinian States.

Early attempts by the government to have it merge with the latter failed in the 1860s as they met local opposition in Tuscany.

Starting from 1874, the Banca Nazionale Toscana was part of the mandatory consortium under which each of the six banks were assigned caps on their respective volumes of issuance.

Like other private banks of issue, Banca Nazionale Toscana was listed on the stock exchange.