In this time, the town named Braničevo also existed in the area, at the estuary of the river Mlava into Danube.

After the conquest of Bulgaria, the Byzantines established the Theme of Sirmium in the wider region south of the river Danube.

With the rise of the Second Bulgarian Empire and the Kingdom of Serbia, Byzantium's position in Braničevo became untenable.

In 1291, they were defeated by the Serbian king, Stefan Dragutin, who joined Braničevo to his Syrmian Kingdom.

In the mid-nineteenth century, at the time of the Serbian state emancipation, Požarevac became, along with Kragujevac, the second metropolis of Prince Miloš Obrenović.