The Barupė starts at Žinėnai village, in Jonava District Municipality.

Labūnava Reservoir dams the Barupė river; smaller ponds are also located in the Barupė valley in Kuigaliai and Labūnava.

[2] Sangailiškiai, Kuigaliai, Pėdžiai, Nociūnai, Serbinai, Labūnava villages are located on the shores of the Barupė.

A part of river's lower course is protected as the Barupė Landscape Sanctuary.

The component upė means 'river' while the root bar- could be of archaic origin, related to Russian: бара 'puddle', Ukrainian: бар 'slough between hills', Illyrian languages: *bar(b)- 'puddle'.