In 2021, Barzilai Medical Center introduced an innovative treatment for chronic skin wounds that combines plastic surgery and orthopedic rehabilitation.

[6] Plans to build a new rocket and missile-proof emergency room for the hospital in 2010 were hampered by ultra-orthodox protests sparked by the discovery of human remains in an ancient burial ground unearthed during construction activities.

[10] An underground protected area was built, accommodating 285 beds, but the hospital still struggles with challenges like caring for premature infants and conducting dialysis treatments under these circumstances.

[7] On 8 October 2023, the second day of the conflict, the hospital administration decided to relocate all patients from the women's and high-risk pregnancy departments to a protected underground area.

The hospital director Hazi Levi emphasized the importance of this pre-emptive action, especially given the severity of damage evident in the aftermath of the rocket strikes.

[7] A section of the grounds of the hospital is believed to have been the burial place of the head of Husayn ibn Ali (Arabic: رَأس ٱلحُسَين, romanized: Rās al-Ḥusayn), a grandson of Muhammad.