Kaplan Medical Center (Hebrew: מרכז רפואי קפלן, Merkaz Refu'i Kaplan) is a district general hospital in Rehovot, Israel, located in the south of the city next to Bilu Junction.

It is owned and operated by Clalit Health Services.

Kaplan Medical Center is a teaching hospital affiliated with Hadassah Medical Center and the Hebrew University of Jerusalem's Medical School.

It also has a small branch in nearby Gedera, the Herzfeld Medical Center, which mainly serves as a geriatric hospital and nursing home.

It was founded in 1953 and was named after Eliezer Kaplan, a well-known Zionist and the first Finance Minister of Israel.