The game sees Zitz travel to the planet Armageddon to rescue fellow Battletoads Rash and Pimple, who have been captured by the Dark Queen's lackey Robo-Manus, who serves as the final boss.

Zitz's mission begins on Armagedda's surface, where Psyko-Pigs and rat-piloted UFOs roam about to destroy intruders.

In the third stage in the dark caverns of Armagedda, Zitz must use the vines to swing across large gaps.

Stage five poses a foot-race in a zig-zagging path in which Zitz must escape from a constantly rolling brain-like boulder while minding the sudden turns and not stopping.

In stage seven, Zitz straps on a jet pack and flies high to the tip-top while avoiding barricades, laser beams, and enemies during the flight under a 99-second time limit.