He returned to the Ottoman Empire, where he practiced as a general practitioner from 1896 until 1911, Then he would travel to Paris where he would specialize in ophthalmology in the hospitals of Quinze Vingt and Hôtel Dieu until 1914.
[2] During the annual meeting of the Medical Society of Athens on November 15, 1930, Adamantiades presented "A case of relapsing iritis with hypopyon"[3] identifying the three major signs of the so-called Adamantiades–Behçet's disease and insisting on a single clinical entity.
He pointed out that the disease can occur for years as a monosymptomatic or oligosymptomatic disorder and that eye involvement and severe prognosis are more common in men than in women.
In addition to Adamantiades–Behçet's disease, Adamantiades described the interstitial keratitis in trachomatic patients to be a bacterial infection and classified the epidemic idiopathic hemeralopia.
[4] Further pioneer works were those on the marginal corneal degeneration, the posterior vitreous detachment, the measurement of the optic fundi and of the ocular pressure as well as investigations on trachoma, uveitis and the pathogenesis of glaucoma.