[1] The Washington Nationals selected Sousa in the 34th round of the 2017 Major League Baseball draft, but he did not sign and returned to Virginia.

[11] On April 9, 2023, Sousa was traded to the Milwaukee Brewers in exchange for cash considerations and international bonus pool space.

[12] He made two appearances for Milwaukee before he was placed on the injured list with left shoulder nerve irritation on June 9.

[15] On August 29, 2023, the Detroit Tigers claimed Sousa from off waivers and optioned to Triple–A Toledo Mud Hens.

On April 4, 2024, Sousa underwent surgery to address thoracic outlet syndrome, ruling him out for the entirety of the season.