He has previously played in MLB for the Seattle Mariners, Baltimore Orioles, San Diego Padres, Los Angeles Dodgers, Boston Red Sox and Oakland Athletics and in Nippon Professional Baseball (NPB) for the Hiroshima Toyo Carp.

[2] After moving, he attended Notre Dame Prep High School in Scottsdale, Arizona.

[5] Scott signed with the Sioux City Explorers of the American Association, an independent baseball league, in April 2016.

[9] Scott became a free agent after the 2018 season, and signed a minor-league contract with the Seattle Mariners on 24 January 2019.

[1] He made his major-league debut on 8 June, becoming the first South African pitcher in MLB history.

[16] On 1 December 2019, Scott signed a one-year contract with the Hiroshima Toyo Carp of Nippon Professional Baseball (NPB).

[citation needed] On 7 March 2022, Scott signed a minor-league contract with the San Diego Padres organization.

[20] In four appearances for the Triple–A Lehigh Valley IronPigs, Scott struggled to a 15.00 ERA with four strikeouts in three innings of work.

[24] He began the season with Triple-A Oklahoma City, allowing only two earned runs in 16+2⁄3 innings before he was called up to the majors on 22 May.

[29] In four games for Boston, Scott pitched 3+2⁄3 innings and surrendered three runs (two earned) on six hits and four walks with two strikeouts.

[35] Scott earned his first major league win on 2 May 2024 when he tossed 1+1⁄3 scoreless innings versus the Cleveland Guardians to support an 8–2 final.