[3] Blanco split the 2017 season between the Quad Cities River Bandits and the Buies Creek Astros, going a combined 6–5 with a 3.38 ERA and 79 strikeouts over 88 innings.

[3] Blanco split the 2019 season between the Tri-City ValleyCats, Corpus Christi, and the Round Rock Express, going a combined 5–2 with a 4.96 ERA and 57 strikeouts over 49 innings.

Blanco exited after seven hitless innings versus the Detroit Tigers on June 16 before Ryan Pressly allowed a single by Wenceel Pérez with two outs in the eighth.

[16] In August 2024, Blanco surpassed his previous career high as a professional in innings pitched (125+1⁄3), split between AAA and MLB in 2023.

[20] Blanco was named the Astros' Pitcher of the Year by the Houston chapter of the Baseball Writers' Association of America (BBWAA).

[22] Blanco made his major league postseason debut on October 1, 2024, in Game 1 of the AL Wild Card Series (WCS).

Tossing two scoreless innings in relief, he maintained the Astros' deficit at 3–1 versus Detroit, who held on to win and eventually sweep the best-of-3 series.