In enzymology, a benzoate—CoA ligase (EC 6.2.1.25) is an enzyme that catalyzes the chemical reaction The 3 substrates of this enzyme are ATP, benzoate, and CoA, whereas its 3 products are AMP, diphosphate, and benzoyl-CoA.
The systematic name of this enzyme class is benzoate:CoA ligase (AMP-forming).
Other names in common use include benzoate-coenzyme A ligase, benzoyl-coenzyme A synthetase, and benzoyl CoA synthetase (AMP forming).
This enzyme participates in benzoate degradation via coa ligation.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2V7B.