Benzoyl-CoA is the thioester derived from benzoic acid and coenzyme A.

The term benzoyl-CoA also include diverse conjugates of coenzyme A and aromatic carboxylic acids.

Benzoyl-CoA is a benzoyl transfer agent for the biosynthesis of hippuric acid.

This intermediate is subsequently converted by a benzophenone 3′-hydroxylase, a cytochrome P450 monooxygenase, leading to the formation of 2,3′,4,6-tetrahydroxybenzophenone.

This enzyme is responsible in part for the reductive dearomatization of aryl compounds mediated by bacteria under anaerobic conditions.