Lucrezia de' Medici was born in Florence on 14 February 1448, the second daughter of Piero di Cosimo de' Medici and Lucrezia Tornabuoni.

In 1461, at the age of about 13, she was married to Bernardo Rucellai with a dowry of 2500 fiorini d'oro.

The wedding feast was famous for its opulence: 500 guests were seated on a triangular dais which occupied the loggia and the whole of the piazza and the street in front of Palazzo Rucellai.

The couple had five children, Cosimo, Piero, Palla, Giovanni and Lucrezia.

[2] Nannina de' Medici died on 14 May 1493 and was buried in the Rucellai Chapel of the church of San Pancrazio in Florence.