Big Creek is a stream in Lincoln, St. Charles and Warren counties of the U.S. state of Missouri.

The source area for the stream lies just southwest of Warrenton in Warren County.

The stream meanders east and becomes the boundary between Lincoln and St. Charles counties.

It passes under US Route 61 and enters the Cuivre to the north of Wentzville, and the communities of Flint Hill and Enon.

[2] According to tradition, the former name was applied because eagles often attacked an early settler's hogs.