Big Pine Creek is a 12.1-mile-long (19.5 km)[1] stream in Inyo County of eastern California, in the western United States.

The headwaters of Big Pine Creek are in the eastern slopes of the Sierra Nevada, near the border with Fresno County.

The canal provides water to the Big Pine area for irrigation, recreation and groundwater recharge.

There are no storage dams or reservoirs, but the Los Angeles Department of Water and Power operates a 3.2 MW hydroelectric plant on the creek, which dewaters it.

The actor Lon Chaney had a stone cabin built on the North Fork of Big Pine Creek, as a personal retreat.